The centerpiece of the thesis is the search for muon neutrino to electron neutrino oscillations which would indicate a non-zero mixing angle between the first and third neutrino generations (?13), currently the holy grail of neutrino physics. The optimal extraction of the electron neutrino oscillation signal is based on the novel library event matching (LEM) method which Ochoa developed and implemented together with colleagues at Caltech and at Cambridge, which improves MINOS (Main Injector Neutrino Oscillator Search) reach for establishing an oscillation signal over any other method. LEM will now be the basis for MINOS final results, and will likely keep MINOS at the forefront of this field until it completes its data taking in 2011. Ochoa and his colleagues also developed the successful plan to run MINOS with a beam tuned for antineutrinos, to make a sensitive test of CPT symmetry by comparing the inter-generational mass splitting for neutrinos and antineutrinos. Ochoas in-depth, creative approach to the solution of a variety of complex experimental problems is an outstanding example for graduate students and longtime practitioners of experimental physics alike. Some of the most exciting results in this field to emerge in the near future may find their foundations in this thesis.