Recent research has unearthed new insights into brain disease. In this volume, leading scientists review the latest experimental and clinical findings on how the central nervous system (CNS) responds to injury. Brain Disease encompasses the mechanisms of CNS disorders, such as multiple sclerosis, Alzheimer's disease, stroke and traumatic brain injury. Attention is focused on the role of genetic and environmental factors, pathophysiology of immune-mediated brain injury, blood-brain barrier eruption and brain edema, apoptotic mechanisms, cytokines, chemokines and the matrix metalloproteinases (MMPs). Other topics include repair mechanisms, gene therapy and the use of stem cells for CNS remyelination, regeneration, neurogenesis and compensatory plasticity. Brain Disease is indispensable for practicing neurologists, neurosurgeons, geriatricians and students in those fields.