This book is a comprehensive monograph on the CtBP family proteins. These proteins are gaining wide scientific interest due to their critical roles in animal development and in oncogenesis. The CtBP family proteins are multifunctional. They predominantly function as transcriptional corepressors in the nucleus by recruiting various histone modifying enzymes such as histone deacetylases, histone methylases and a histone demethylase. They also perform several diverse cytosolic functions such as Golgi maintenance and in central nervous system synapses.