Critical Care Clinicians can use general drug references (Micomedex, Lexicomp) for data on dosing of high-alert medications in special patient populations but these references are not available to all healthcare clinicians, they are expensive and they are not specific to high-alert medications or critically ill patients. Doctors, nurses and pharmacists in the hospital setting will benefit from having one resource with all of this information. The purpose of this reference manual would be to guide critical care clinicians on dosing of high-alert medications in special patient populations. The most important feature of the book will be a summary of primary literature using tables when possible. This will be useful to readers because currently a reference book does not exist that guides clinicians in these difficult dosing decisions.