James D. Reimann, Sharon Safrin, and Robert B. Fick, Jr.Understanding the Binding of IgE to Its High-Affinity Receptor and to an Anti-IgE AntibodyLeonard G. Presta and Robert L. ShieldsMediator Release from Basophils and Mast Cells and Its Relationship to FceRI Expression and IgE-Suppressing TherapiesDonald W. MacGlashan, Jr., John T. Schroeder, Lawrence M. Lichtenstein, Sarbjit S. Saini, and Bruce S. BochnerExpression of IgE Receptors on Eosinophils David Dombrowicz, Andre Capron, and Monique CapronEosinophil IgE Receptors: Controversy and Consensus Hirohito Kita and Cheryl R. AdolphsonMurine Models of Asthma: Caveats and Conclusions on the Contribution of IgE and Mast Cells to Allergic Inflammation, Airway Hyperresponsiveness, and Airflow ObstructionJeffrey S. Tepper and Daniel B. TumasRole of IgE in Asthma: Pathogenesis and Novel Therapeutic StrategiesJames Laurence Lordan, Stephen T. Holgate, and Ian SayersIgE-Mediated Response to Allergen in the Bronchoprovocation LaboratoryLouis-Philippe Boulet and Donald W. CockcroftPathophysiology of the Airway Response to Inhaled Allergen in Asthmatic Subjects: Role of IgEJohn V. FahyEfficacy and Safety of Xolair Anti-IgE Monoclonal Antibody in Adult AsthmaticsRobert B. Fick, Jr., and W. James MetzgerThe Role of IgE in Pediatric Asthma Henry Milgrom and Charles JohnsonAnti-inflammatory Activities of Omalizumab (Xolair), a Recombinant Humanized Monoclonal Antibody Binding IgERobert B. Fick, Jr.Pulmonary Delivery of Anti-IgE: Rationale for Topical Delivery to the AirwayTheresa D. Sweeney, Melinda Marian, Jane Ruppel, and Jeanine L. BussiereTreatment of Seasonal Allergic Rhinitis Thomas B. Casale and Patricia W. RohaneAnti-IgE and Allergic Skin Diseases Michael F. Hofer and Donald Y. M. LeungRole of IgE and Food Allergens Ricki M. Helm and A. Wesley BurksRole of IgE in Allergic Bronchopulmonary Aspergillosis Priscilla S. A. Sarinas and Rajinder K. ChitkaraIgE and Its Role in Parasitic Helminth Infection: Implications for Anti-IgE-Based TherapiesPhilip J. Cooper and Thomas B. NutmanThe Rise of Antibodies as Therapeutics Maureen P. Quan and Paul CarterAuthor Index current research on the mechanisms and utilization of anti-IgE therapeutics in the treatment of IgE-mediated allergic disease, inflammation, and asthma-discussing the structural composition of high- and low-affinity IgE receptors, the airway cells that express these receptors, and the functional activity of IgE-FceRI and IgE-FceRII interactions for improved control and management of allergic disorders.Compiles previously unpublished data from the first extensive scientific investigations of Xolair!IgE and Anti-IgE Therapy in Asthma and Allergic Diseasereviews studies on the distribution of serum IgE levels of normal and asthmatic populations in developed regions of the world such as the United States, Canada, Scandinavia, New Zealand, and Europe offers novel methods for the design and formulation of monoclonal antibodies discusses the use of allergen bronchoprovocation to identify the characteristics and efficacy of new antiasthma and antiallergy medications examines the role of IgE in food and parasitic allergiesand coversthe pathogenesis of atopic dermatitis and urticaria novel strategies to target mast cells and basophils murine models of allergic pulmonary inflammation the pathophysiology of allergic rhinitisSupplemented with nearly 2000 contemporary references to facilitate further study, IgE and Anti-IgE Therapy in Asthma and Allergic Disease is an in-depth and timely source for basic and clinical immunologists; allergists; pulmonologists and pulmonary disease specialists; physiologists; molecular, cellular, and lung biologists; pediatricians; internists; and graduate and medical school students in these disciplines.

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