Recent experimental results with direct bearing on theories of cosmological dark matter/energy, as well as continuing work on neutrino masses and mixing, have invigorated both particle physics and cosmology, and should continue to do so well into the 21st century, thereby launching a beautiful new epoch for these fields. The expert contributions from this conference took stock of these developments. This volume contains papers by over 40 physicists that summarize and interpret the newest findings, and suggest future avenues to be explored. A number of new theoretical ideas are also presented, dealing with progress in understanding the dynamics and symmetries of strings and branes, renormalization in quantum field theory, possible Lorentz violation effects, and related problems. Ongoing and next generation gravitational and neutrino experiments are described, and the issues of unification are dealt with in the context of, and beyond, the standard model. Together, the contributions provide a useful blend of experimental and theoretical physics from many prominent physicists, including three Nobel Laureates. The volume also contains information of an historical nature, concerning the contributions to physics by Paul Frampton, on the occasion of his 60th year, and summarizing the career of Behram Kursunoglu (1922–2003).