The ever increasing complexity of modern electronic devices together with the continually shrinking time-to-market and product lifetimes pose enormous chip design challenges to meet flexibility, performance and energy efficiency constraints. As a consequence, the current trend is towards programmable platforms (Multi-Processor System-on-Chip Platforms, MP-SoC), which are tailored to the respective target application. In the usual case, a new platform is designed by selecting and assembling standard platform elements. The first chapters of this book summarize the state of the art in all three involved fields separately: general system level design, communication modeling, and processor modeling. The main chapters then present a methodology and the associated tooling for enabling design space exploration as well as a successive refinement flow for the design of optimized MP-SoCs with a high degree of automation.