The 2005 meeting in Taormina, Italy was attended by 127 professionals who develop and use the highest quality detectors for wavelengths from x-ray to sub-mm, with emphasis on optical and infrared detectors. The meeting consisted of overview talks, technical presentations, poster sessions and roundtable discussions. These proceedings capture the technical content and the spirit of the 2005 workshop. The 87 papers cover a wide range of detector technologies including CCDs, CMOS, APDs, and sub-mm detectors. There are papers on observatory status and plans, special applications, detector testing and characterization, and electronics. A special feature of these proceedings is the inclusion of pedagogical overview papers, which were written by teams of leading experts from different institutions. These proceedings are appropriate for a range of expertise levels, from undergraduates to professionals working in the field. The information presented in this book will serve as a valuable reference for many years to come. This workshop was organized by the Scientific Workshop Factory, Inc. and the INAF- Osservatorio Astrofisico di Catania.