Particle Physics and High Energy Physics have stagnated since the early 1970s. Now, the underlying principle of reductionism — so sacred to twentieth-century physics — is itself being questioned. This book examines these tumultuous developments that are leading to a paradigm shift and a new horizon for Physics.Presenting the new paradigm in fuzzy spacetime, this book is based on some 100 papers published in peer-reviewed journals including Foundations of Physics, Nuovo Cimento and The International Journal of Modern Physics (A&E), as well as two recently published books, The Chaotic Universe (Nova Science, New York) and The Universe of Fluctuations (Springer). The work had predicted correctly in advance epoch-turning observations, for example, that the Universe is accelerating with a small cosmological constant driven by dark energy when the prevalent line of thinking was the exact opposite. Similarly, the prediction of a minimum thermodynamic residual energy in the Universe has also been realized more recently. Further to a unified description of gravitation and electromagnetism via fluctuations, several other features are presented in complete agreement with experiments, in sharp contrast to the present ideas which are neither verifiable nor disprovable.