Time-domain Beamforming and Convolutive Blind Source Separation addresses the problem of separating spontaneous multi-party speech by way of microphone arrays (beamformers) and adaptive signal processing techniques. While existing techniques requires a Double-Talk Detector (DTD) that interrupts the adaptation when the target is active, the described method addresses the separation problem using continuous, uninterrupted adaptive algorithms. The advantage of such an approach is twofold: Firstly, the algorithm development is much simpler since no detection mechanism needs to be designed and no threshold to be tuned. Secondly, the performance can be improved due to the adaptation during periods of double-talk. The book is written is a concise manner and an effort has been made such that all presented algorithms can be straightforwardly implemented by the reader. All experimental results have been obtained with real in-car microphone recordings involving simultaneous speech of the driver and the co-driver, as opposed to computer-generated simulations. Experiments with background noise have been carried out in order to assess the robustness of the considered methods in noisy conditions.